Use of mean airspace chord length to assess emphysema
نویسندگان
چکیده
منابع مشابه
Use of mean airspace chord length to assess emphysema.
THERE IS CURRENTLY a great deal of interest in mechanisms underlying COPD. Although COPD is not a term commonly applied to mouse models, in mice there has been an increasing number of studies in recent years on one of the hallmarks of COPD, i.e., emphysema. Emphysema is characterized by destruction of alveolar walls, with concomitant loss of alveolar surface area, enlargement of airspaces, and ...
متن کاملCommentaries on viewpoint: use of mean airspace chord length to assess emphysema. Mean airspace chord length is useful in assessing emphysema.
TO THE EDITOR: Although mean airspace chord length (Lm) lacks the elegance of some stereology methods and requires careful attention to technique (4), Mitzner (3) argues that Lm has utility in studying experimental emphysema. Clearly, Lm reflects the dimensions of alveoli but is not a direct estimate of alveolar diameter or mean alveolar size. The functional significance of Lm lies, however, in...
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The mean linear intercept (L(m)) can be used to estimate the surface area for gas exchange in the lung. However, in recent years, it is most commonly used as an index for characterizing the enlargement of airspaces in emphysema and the associated severity of structural destruction in the lung. Specifically, an increase in L(m) is thought to result from an increase in airspace sizes. In this pap...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2008
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.90968.2008